Research

Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model

DOI: 10.3390/ijms17081293 Summary: The goal of this study was to investigate whether oleuropein (OLE), the major phenolic compound in olive derivatives, may prevent neuronal degeneration in a cellular dopaminergic model...

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender2018

DOI: 10.3390/ijms19123948 Summary: The aim of our study was to establish whether the positive Ole-related effects on liver steatosis could be associated with autophagy. Female and male C57BL/6J mice were...

Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM

DOI: 10.3892/mmr.2020.11572 Summary: This study aimed to investigate the effects of apigenin on cell proliferation and apoptosis of human melanoma cells A375P and A375SM. Therefore, melanoma cells were treated with...

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

DOI: 10.1016/j.biopha.2018.04.072 Keywords: Apigenin; Apoptosis; Autophagy; PI3K/Akt/mTOR. Research paper authors: Jiali Yang, Cuicui Pi, Guanghui Wang

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels

DOI: 10.1038/s42255-020-00298- Summary: Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is...

CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD +/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats

DOI: 10.18632/aging.103410 Keywords: CD38; Sirt3; diabetic kidney disease; mitochondrial oxidative stress. Research paper authors: Yoshio Ogura, Munehiro Kitada, Jing Xu, Itaru Monno, Daisuke Koya

Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells

DOI: 10.3390/nu10091320 Keywords: Helicobacter pylori; astaxanthin; gastric epithelial cells; mitochondrial dysfunction; reactive oxygen species. Research paper authors: Suhn Hyung Kim, Joo Weon Lim, Hyeyoung Kim

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

DOI: 10.3390/nu10091137 Keywords: astaxanthin; disease prevention; mitochondrial dysfunction; oxidative stress. Research paper authors: Suhn Hyung Kim, Hyeyoung Kim

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

DOI: 10.1016/j.cmet.2011.08.014 Summary: This study overviews that NMN enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. Furthermore,...